Protein Details: Transient receptor potential cation channel subfamily M member 2
Protein ID
ICDB_Pro_0288
Protein Name
Transient receptor potential cation channel subfamily M member 2
Gene Name
TRPM2; EREG1; KNP3; LTRPC2; TRPC7
Organism
Homo sapiens (Human)
Length
1503 amino acids
AlphaFoldDB
AF-O94759-F1-model_v4.pdb
Function
Sequence
Ligand Binding
Binding Site
843;846;869;1073
Disease
Choroid Disease and Choroiditis
Location
Highly expressed in brain and peripheral blood cells; such as neutrophils. Also detected in bone marrow; spleen; heart; liver and lung. Isoform 2 is found in neutrophil granulocytes. Isoform 2 is found in neutrophil granulocytes. Isoform 2 is found in neutrophil granulocytes.
DOI ID
10.1006/geno.1998.5551; 10.1074/jbc.m112096200; 10.1074/jbc.m300298200; 10.1016/j.bbrc.2005.01.086; 10.1038/35012518; 10.1038/35079100; 10.1126/science.1062473; 10.1016/s1097-2765(01)00438-5; 10.1074/jbc.m411446200; 10.1038/sj.emboj.7601083; 10.1085/jgp.200810109; 10.1126/scisignal.2000278; 10.1074/jbc.m109.066464; 10.1074/jbc.m110.139774; 10.1073/pnas.1114193109; 10.1042/bj20140747; 10.1085/jgp.201511377; 10.1038/srep08032; 10.7554/elife.17600; 10.1242/jcs.179796; 10.1038/s41598-017-07652-4; 10.7554/elife.36409; 10.1126/science.aav4809
RefSeq
NP_001307279.1; NP_001307280.1; NP_003298.1 [O94759-1]; XP_005261228.1